PathwayViz is a web-based tool for users to upload their gene expression comparison data and overlay it on three gene pathway diagrams: WikiPathways, Reactome Pathways, and KEGG Pathways.
Getting Started with PathwayViz:
Gene pathway databases are crucial resources in bioinformatics and systems biology. They provide structured information about biological processes, gene interactions, and molecular functions. Here's an overview of major gene pathway databases:
WikiPathways is a collaborative platform for creating, editing, and sharing biological pathways.
Reactome is a free, open-source, curated and peer-reviewed pathway database.
KEGG is a comprehensive database resource for understanding high-level functions and utilities of biological systems.
Feature | WikiPathways | Reactome | KEGG |
---|---|---|---|
Access | Free, open | Free, open | Free for academic use |
Curation | Community | Expert-curated | Expert-curated |
Species coverage | Multiple | Primarily human | Wide range |
Integration | High | High | High |
Visualization tools | Yes | Yes | Yes |
API availability | Yes | Yes | Yes |
Each of these databases offers unique features and strengths. Researchers often use a combination of these resources for comprehensive pathway analysis and interpretation. The choice of database often depends on the specific research question, organism of interest, and the type of pathway information required.
It's important to note that many of these databases integrate data from each other and from primary literature sources. Therefore, using multiple databases can provide a more comprehensive view of biological pathways and gene interactions.